Search on: CYCLIN-DEPENDENT KINASE INHIBITOR P16 
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Descriptor English:   Cyclin-Dependent Kinase Inhibitor p16 
Descriptor Spanish:   Inhibidor p16 de la Quinasa Dependiente de Ciclina 
Descriptor Portuguese:   Inibidor p16 de Quinase Ciclina-Dependente 
Tree Number:   D12.644.360.225.200
D12.776.167.187.200
D12.776.476.225.200
D12.776.624.776.355.200
Definition English:   A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions. 
See Related English:   Genes, p16
Tumor Suppressor Protein p14ARF
 
History Note English:   2006(1994) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   33490 
Unique Identifier:   D019941 

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